For Protein Engineers

Fold, Design & Optimize Proteins — No GPU Required

Run ESMFold, Boltz-2, ProteinMPNN, and stability prediction in seconds. Paste a sequence, get a structure. Free for researchers.

No install · No GPU · Free for .edu emails (750 credits/month)

The Protein Engineering Pipeline

Four steps from sequence to optimized protein — each running on cloud GPUs so you don't have to.

1

Fold

Predict 3D structure from sequence

ESMFold
~3s5 cr
Boltz-2Complex
~30s20 cr
2

Design

Inverse-fold sequences for a backbone

ProteinMPNN
~5s8 cr
RFdiffusionDe novo
~15s12 cr
3

Stabilize

Predict mutation effects on stability

ThermoMPNN
~1s3 cr
4

Express

Predict solubility and expression

SoluProt
~1s2 cr

ESMFold vs Boltz-2 vs AlphaFold

The most common question from our search traffic, answered with real numbers.

FeatureESMFoldBoltz-2AlphaFold
InputSequence onlySequence + ligandsSequence + MSA
Speed~3 seconds~30 seconds~minutes
MSA required?NoNoYes
ComplexesMonomer onlyProtein + ligand + DNAMultimer (v2.3+)
GPU needed?No (SciRouter)No (SciRouter)Yes (local)
Cost on SciRouter5 credits ($0.05)20 credits ($0.20)N/A (self-host)
Best forFast screeningComplexes + accuracyGold-standard single chains

Frequently Asked Questions

Start folding proteins in 30 seconds

Paste a sequence, get a structure. No GPU, no install, no waiting. Free for researchers — 500 credits/month, 750 for .edu.