AntibodiesGPU12 credits

AntiFold — Antibody CDR Design

Design antibody CDR sequences using inverse folding

AntiFold designs CDR sequences for given antibody backbone structures using an inverse folding model fine-tuned from ESM-IF1 on antibody crystal structures. Generate diverse, high-affinity CDR variants for therapeutic antibody optimization.

$0.12

per API call

credits per call

/v1/antibodies/design

API endpoint

Features

CDR sequence design from backbone structure

Fine-tuned from ESM-IF1 on antibody structures

Multiple CDR loop design (H1, H2, H3, L1, L2, L3)

Temperature sampling for diversity

Framework region preservation

GPU-accelerated inference

Quick Start

AntiFold — Python Examplepython

import requests

API_KEY = "sk-sci-your-key-here"
url = "https://scirouter.ai/v1/antibodies/design"

response = requests.post(url, json={
    "pdb": open("antibody.pdb").read(),
    "design_cdrs": ["H3", "L3"],
    "num_sequences": 10,
    "temperature": 0.2
}, headers={"Authorization": f"Bearer {API_KEY}"})

result = response.json()
for design in result["designs"]:
    print(f"Score: {design['score']:.3f}")
    print(f"  H3: {design['cdr_sequences']['H3']}")
    print(f"  L3: {design['cdr_sequences']['L3']}")