ImmunologyHybrid7 credits

Neoantigen Pipeline

End-to-end: variant analysis, peptide generation, MHC binding, ranking

Complete neoantigen discovery pipeline: analyze mutations with ESM-1v, generate candidate peptides, predict MHC binding with netMHCpan, and rank candidates by immunogenic potential.

$0.07

per API call

credits per call

/v1/immunology/neoantigen_pipeline

API endpoint

Features

Variant effect analysis with ESM-1v

Neoantigen peptide generation

MHC Class I binding prediction

Candidate ranking and filtering

Multi-allele support

Combined pathogenicity + binding scoring

Quick Start

ESM-1v + netMHCpan — Python Examplepython

import requests

API_KEY = "sk-sci-your-key-here"
url = "https://scirouter.ai/v1/immunology/neoantigen_pipeline"

response = requests.post(url, json={
    "gene": "KRAS",
    "mutations": ["G12D", "G12V"],
    "hla_alleles": ["HLA-A*02:01", "HLA-A*03:01"]
}, headers={"Authorization": f"Bearer {API_KEY}"})

result = response.json()
for candidate in result["candidates"][:5]:
    print(f"{candidate['peptide']}: rank={candidate['rank']:.2f}%, "
          f"score={candidate['combined_score']:.3f}")