GenomicsHybrid5 credits

Variant Effect Prediction

Score mutation pathogenicity and generate neoantigen peptides

Predict the functional impact of amino acid substitutions using ESM-1v language model scores combined with ClinVar clinical annotations. Generate neoantigen peptides for downstream immunology analysis.

$0.05

per API call

credits per call

/v1/genomics/variant_effect

API endpoint

Features

Pathogenicity scoring with ESM-1v

ClinVar clinical annotation lookup

Neoantigen peptide generation

Support for common mutation formats

Cancer variant context from COSMIC

Batch mutation processing

Quick Start

ESM-1v + ClinVar — Python Examplepython

import requests

API_KEY = "sk-sci-your-key-here"
url = "https://scirouter.ai/v1/genomics/variant_effect"

response = requests.post(url, json={
    "gene": "BRAF",
    "mutation": "V600E"
}, headers={"Authorization": f"Bearer {API_KEY}"})

result = response.json()
print(f"Pathogenicity: {result['pathogenicity_score']:.3f}")
print(f"ClinVar: {result['clinvar_significance']}")
print(f"Neoantigens: {len(result['neoantigen_peptides'])}")