DarkScan V2 · production
DarkScan V2 is our neoantigen discovery pipeline — an intelligent funnel that reduces ~700–1,000× the candidate space vs naive enumeration without sacrificing recall. Every canine vaccine SciRouter ships starts here.
The funnel
Stage 1
~10⁵–10⁶
Variants called
raw tumor vs normal variants
Stage 2
~10⁴
Expressed in tumor
RNA-seq filter
Stage 3
~10³
MHC-presentable
DLA-88 / DLA-12 binding (canine)
Stage 4
~10²
Non-self
host proteome subtraction
Stage 5
10–30
Top ranked
Sci-JEPA + immunogenicity scoring
Each stage applies a learned or rule-based filter — the speedup comes from doing inexpensive filters first and reserving Sci-JEPA + immunogenicity inference for the ~10³ candidates that survive the upstream funnel.
The numbers
vs. naive O(N×alleles) enumeration on the same hardware. The funnel structure does the work.
from raw VCF + RNA expression to a ranked peptide list with rationale. A clinical case fits in a coffee + walk-the-dog cycle.
compute amortized on RunPod A100 80GB. Orchestration runs on a $7/month Railway dyno. The asset-light story is real.
What lands on the vet's desk
Excerpt from the SR-OST-001 case study (canine appendicular osteosarcoma, distal radius, 9-year-old Rottweiler).